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Abstract
Exposure to alloantigen via the anterior chamber of the eye elicits a transient suppression of cellular immunity, whereas humoral immunity is preserved—i.e. F1 LI-ID. The majority of lymphoid cells inoculated into the anterior chamber are retained within the posterior segment of the eye. The latter serves as a depot of alloantigen, allowing the chronic egress of small numbers of cells into the vascular tree. The persistence of this antigen depot is essential to the development of F1 LI-ID. Since there is a preferential distribution of cells that migrate from the eye to the spleen, the functional integrity of the latter is also necessary to elicit F1 LI-ID. It is concluded that an anatomically intact spleen, i.v. presentation of antigen, and persistence of antigen within the eye are all important to the elicitation of this phenomenon.
| 3Abbreviations used in this paper | ||
| F1 LI-ID, | = | F1 lymphocyte-induced-immune deviation; |
| FI, | = | Fischer; |
| DA, | = | Dark Agouti; |
| HBSS, | = | Hanks' balanced salt solution; |
| NRS, | = | normal rat serum; |
| NRbS, | = | normal rabbit serum: |
| GVH, | = | graft-vs-host; |
| HVG, | = | host-vs-graft; |
| fp, | = | footpad; |
| MST, | = | median survival time. |
| 3Abbreviations used in this paper | ||
| F1 LI-ID, | = | F1 lymphocyte-induced-immune deviation; |
| FI, | = | Fischer; |
| DA, | = | Dark Agouti; |
| HBSS, | = | Hanks' balanced salt solution; |
| NRS, | = | normal rat serum; |
| NRbS, | = | normal rabbit serum: |
| GVH, | = | graft-vs-host; |
| HVG, | = | host-vs-graft; |
| fp, | = | footpad; |
| MST, | = | median survival time. |