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Ocular Immunology and Inflammation Volume 15, 2007 - Issue 3
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ARTICLES

Vascular Endothelial Growth Factor Receptor-3 Mediates Induction of Corneal Alloimmunity

Lu Chen Laboratory of Immunology, Schepens Eye Research Institute and the Massachusetts Eye and Ear Infirmary, Harvard Medical School, 20 Staniford Street, Boston, Massachusetts, USA; Department of Ophthalmology, Harvard Medical School, 20 Staniford Street, Boston, Massachusetts, USA
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Pedram Hamrah Laboratory of Immunology, Schepens Eye Research Institute and the Massachusetts Eye and Ear Infirmary, Harvard Medical School, 20 Staniford Street, Boston, Massachusetts, USA; Department of Ophthalmology, Harvard Medical School, 20 Staniford Street, Boston, Massachusetts, USA
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Claus Cursiefen Laboratory of Immunology, Schepens Eye Research Institute and the Massachusetts Eye and Ear Infirmary, Harvard Medical School, 20 Staniford Street, Boston, Massachusetts, USA; Department of Ophthalmology, Harvard Medical School, 20 Staniford Street, Boston, Massachusetts, USA
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Qiang Zhang Laboratory of Immunology, Schepens Eye Research Institute and the Massachusetts Eye and Ear Infirmary, Harvard Medical School, 20 Staniford Street, Boston, Massachusetts, USA; Department of Ophthalmology, Harvard Medical School, 20 Staniford Street, Boston, Massachusetts, USA
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Bronislaw Pytowski ImClone Systems, 180 Varick Street, New York, New York, USA
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J Wayne Streilein Laboratory of Immunology, Schepens Eye Research Institute and the Massachusetts Eye and Ear Infirmary, Harvard Medical School, 20 Staniford Street, Boston, Massachusetts, USA; Department of Ophthalmology, Harvard Medical School, 20 Staniford Street, Boston, Massachusetts, USA
&
M Reza Dana Laboratory of Immunology, Schepens Eye Research Institute and the Massachusetts Eye and Ear Infirmary, Harvard Medical School, 20 Staniford Street, Boston, Massachusetts, USA; Department of Ophthalmology, Harvard Medical School, 20 Staniford Street, Boston, Massachusetts, USA
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Pages 275-278 | Accepted 16 Jun 2004, Published online: 08 Jul 2009
 
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Abstract

There are no studies so far linking molecular regulation of lymphangiogenesis and induction of adaptive immunity. Here, we show that blockade of vascular endothelial growth factor receptor-3 (VEGFR-3) signaling significantly suppresses corneal antigen-presenting (dendritic) cell trafficking to draining lymph nodes, induction of delayed-type hypersensitivity and rejection of corneal transplants. Regulating the function of VEGFR-3 may therefore be a mechanism for modulating adaptive immunity in the periphery.

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