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Ocular Immunology and Inflammation Volume 16, 2008 - Issue 5-6
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Original Reports

Distinct Cytokine Patterns in the Aqueous Humor of Children, Adolescents and Adults with Uveitis

Karen M. Sijssens Department of Ophthalmology, University Medical Center Utrecht, Utrecht, The Netherlands
, MD,
Ger T. Rijkers Department of Pediatric Immunology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Nieuwegein, The Netherlands; Department of Medical Microbiology and Immunology, St. Antonius Hospital, Nieuwegein, The Netherlands
, PhD,
Aniki Rothova Department of Ophthalmology, University Medical Center Utrecht, Utrecht, The Netherlands
, MD, PhD,
Jan S. Stilma Department of Ophthalmology, University Medical Center Utrecht, Utrecht, The Netherlands
, MD, PhD &
Joke H. de Boer MD, PhD Department of Ophthalmology, University Medical Center Utrecht, Utrecht, The Netherlands
Pages 211-216 | Received 16 Jun 2008, Accepted 11 Aug 2008, Published online: 08 Jul 2009
 
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Abstract

Purpose: To determine the immune mediator profile in relation to age in the aqueous humor (AqH) of patients with uveitis. Methods: AqH of children, adolescents, and adults with uveitis was analyzed for 16 immune mediators. Results: No significant differences were found for IL-8, RANTES, and IP-10. The concentrations of the remaining 13 mediators were significant lower in adults compared with children and adolescents, except for IL-6, which was higher. Conclusions: Various immune mediators are present in higher concentrations in AqH of children and adolescents with different uveitis entities compared with that of adults, except IL-6, which was higher in adults.

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