Autoinflammation and HLA-B27: Beyond Antigen Presentation

ABSTRACT

HLA-B27 associated disorders comprise a group of inflammatory conditions which have in common an association with the HLA class I molecule, HLA-B27. Given this association, these diseases are classically considered disorders of adaptive immunity. However, mounting data are challenging this assumption and confirming that innate immunity plays a more prominent role in pathogenesis than previously suspected. In this review, the concept of autoinflammation is discussed and evidence is presented from human and animal models to support a key role for innate immunity in HLA-B27 associated disorders.

Keywords:

• Autoinflammation
• HLA-B27
• IL-1
• innate
• spondyloarthritis

DECLARATION OF INTEREST

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

FUNDING

Funding was received from the National Institute of Arthritis and Musculoskeletal and Skin Diseases.

Additional information

Funding

Funding was received from the National Institute of Arthritis and Musculoskeletal and Skin Diseases.