Review for Diagnostics of the Year: Multimodal Imaging in Behçet Uveitis

ABSTRACT

Behçet disease is a chronic relapsing multisystem inflammatory disorder. Ocular involvement is characterized by a bilateral recurrent non-granulomatous panuveitis and retinal vasculitis. Posterior segment findings vary during the course of the disease, in parallel with the relapsing and remitting intraocular inflammation. Structural alterations occur with increased disease duration. Fluorescein angiography is the gold standard in revealing the extent and severity as well as the leaky and/or occlusive nature of retinal vasculitis. Multimodal imaging using color fundus photography, fluorescein angiography, and optical coherence tomography is essential in visualizing diagnostic features, detecting structural changes, and monitoring disease activity and response to treatment in patients with Behçet uveitis.

Keywords:

• Behçet uveitis
• fundus fluorescein angiography
• indocyanine green angiography
• multimodal imaging
• optical coherence tomography

DECLARATION OF INTEREST

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

FUNDING

Ilknur Tugal-Tutkun has received financial support outside the submitted work, including honoraria from Servier, AbbVie, Santen, and Allergan. Imaging studies using the Heidelberg Retina Angiography and Spectralis OCT device (Heidelberg Engineering, Heidelberg, Germany) at Istanbul University, Istanbul Faculty of Medicine, Department of Ophthalmology were supported by the Istanbul University Scientific Projects (project number 25575).

Additional information

Funding

Ilknur Tugal-Tutkun has received financial support outside the submitted work, including honoraria from Servier, AbbVie, Santen, and Allergan. Imaging studies using the Heidelberg Retina Angiography and Spectralis OCT device (Heidelberg Engineering, Heidelberg, Germany) at Istanbul University, Istanbul Faculty of Medicine, Department of Ophthalmology were supported by the Istanbul University Scientific Projects (project number 25575).