Vision-related Quality of Life in Patients with Non-infectious Uveitis: A Cross-sectional Study

ABSTRACT

Purpose: To analyze the influence of socio-demographic, comorbidity, and clinical-related variables in the vision-related quality of life (VR-QoL) of non-infectious uveitis patients.

Methods: Cross-sectional study includes 156 consecutive non-infectious uveitis patients from a tertiary uveitis clinic from Madrid (Spain). The main outcome was the log-transformed composite score of the Visual Functioning Questionnaire 25. Bivariate and multivariate ordinary least-squares regression models were performed and results expressed using effect sizes with 95% confidence intervals (95% CI).

Results: In the multivariate analysis, one unit increase in the logarithm of the minimum angle of resolution scale [i.e., worse best corrected visual acuity (BCVA)] was associated with a seven times worse VR-QoL (a 0.14-fold change [95% CI: 0.07–0.27]). Patients with ocular comorbidities had a 64% worse VR-QoL (a 0.61-fold change [95% CI: 0.49–0.77]).

Conclusions: Lower BCVA and the presence of ocular comorbidities had a significant, independent, and deleterious effect in the VR-QoL of non-infectious uveitis patients.

Keywords:

• Cross-sectional study
• ocular comorbidities
• uveitis
• vision-related quality of life
• visual acuity

ACKNOWLEDGMENTS

The authors thank Isabel Huerta-Miranda and Carlos García-Prieto (Universidad Complutense Medical School, Madrid) for their help in reviewing the clinical records.

DECLARATION OF INTEREST

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

Funding

This work was supported by the Instituto de Salud Carlos III (ISCIII), Ministry of Health, Spain (Miguel Servet research contract: CP12/03129 to LRR). Funders had no role in the design, collection, management, analysis, interpretation of the data, preparation, review, approval, or decision to submit the manuscript for publication.

SUPPLEMENTAL MATERIAL

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Additional information

Funding

This work was supported by the Instituto de Salud Carlos III (ISCIII), Ministry of Health, Spain [Miguel Servet research contract: CP12/03129 to LRR]. Funders had no role in the design, collection, management, analysis, interpretation of the data, preparation, review, approval, or decision to submit the manuscript for publication.