Advanced search
Publication Cover
Ocular Immunology and Inflammation Volume 27, 2019 - Issue 1
Submit an article Journal homepage
428
Views
33
CrossRef citations to date
0
Altmetric
Original Articles

Rapid and Sustained Efficacy of Golimumab in the Treatment of Multirefractory Uveitis Associated with Behçet’s Disease

Claudia FabianiDepartment of Ophthalmology, Humanitas Research Center, Rozzano (Milan), ItalyCorrespondence[email protected] [email protected]
, MD, PhD,
Jurgen SotaResearch Center of Systemic Autoinflammatory Diseases, Behçet’s Disease Clinic and Rheumatology-Ophthalmology Collaborative Uveitis Center, Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Siena, Italy
, MD,
Donato RiganteInstitute of Pediatrics, Università Cattolica Sacro Cuore, Fondazione Policlinico Universitario A. Gemelli, Rome, Italy
, MD, PhD,
Antonio VitaleResearch Center of Systemic Autoinflammatory Diseases, Behçet’s Disease Clinic and Rheumatology-Ophthalmology Collaborative Uveitis Center, Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Siena, Italy
, MD,
Giacomo EmmiDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy
, MD, PhD,
Lorenzo VannozziDepartment of Surgery and Translational Medicine, Eye Clinic, University of Florence, Florence, Italy
, MD,
Rossella FranceschiniOphthalmology Unit of the Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy
, MD,
Daniela BacheriniDepartment of Surgery and Translational Medicine, Eye Clinic, University of Florence, Florence, Italy
, MD,
Bruno FredianiResearch Center of Systemic Autoinflammatory Diseases, Behçet’s Disease Clinic and Rheumatology-Ophthalmology Collaborative Uveitis Center, Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Siena, Italy
, MD,
Mauro GaleazziResearch Center of Systemic Autoinflammatory Diseases, Behçet’s Disease Clinic and Rheumatology-Ophthalmology Collaborative Uveitis Center, Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Siena, Italy
, MD,
Gian Marco TosiOphthalmology Unit of the Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy
, MD, PhD &
Luca CantariniResearch Center of Systemic Autoinflammatory Diseases, Behçet’s Disease Clinic and Rheumatology-Ophthalmology Collaborative Uveitis Center, Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Siena, ItalyORCID Iconhttp://orcid.org/0000-0002-7352-1275
, MD, PhD ORCID Icon show all
Pages 58-63 | Received 31 May 2017, Accepted 03 Jul 2017, Published online: 05 Oct 2017
 
Sample our Medicine, Dentistry, Nursing & Allied Health journals, sign in here to start your FREE access for 14 days

ABSTRACT

Purpose: To evaluate golimumab (GOL) efficacy in the management of Behçet’s disease (BD)-related uveitis.

Methods: We retrospectively collected data from 5 patients (8 eyes) with at least two recent relapses of uveitis, treated with GOL at the standard dose of 50 mg every 4 weeks.

Results: A complete control of intraocular inflammation was observed in 7/8 eyes (87.5%) at 12-month follow-up. The number of relapses 12 months before and after GOL initiation was 11 and 1, respectively. At baseline, four eyes had active retinal vasculitis (RV). At 3-month follow-up evaluation RV resolved in all eyes. Mean Best Corrected Visual Acuity was 6.93 ± 4.34 at baseline and 7.32 ± 3.87 at 12-months follow-up.

Conclusion: We confirm GOL efficacy in reducing intraocular inflammation in BD, both in term of reduction in the number of uveitis relapses and in achieving a prompt resolution of active RV.

DECLARATION OF INTEREST

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

Log in via your institution

Access through your institution

Log in to Taylor & Francis Online

Restore content access

Restore content access for purchases made as guest
Purchase options * Save for later

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 65.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 815.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.