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ABSTRACT
Purpose: To analyze the clinical features and long-term prognosis of uveitis in tubulointerstitial nephritis and uveitis (TINU) syndrome in a cohort of Chinese patients.
Methods: A total of 32 patients with TINU syndrome between 2000 - 2016 were analyzed retrospectively.
Results: Mild anterior inflammation was observed in all cases. Ultra-wide-field fluorescence angiography (UWFA) was conducted on 13 patients, and peripheral vascular leakage was observed in 22/26 eyes (84.62%) compared with active anterior chamber inflammation in 13/26 eyes (50%). Three patients received increased corticosteroid dosage therapy on their first episode of uveitis guided by UWFA had stopped steroids without recurrence.
Conclusion: The uveitis in TINU syndrome was mild. Corticosteroids were efficient in most cases, but a slower tapering and long-term treatment were required. UWFA is sensitive in detecting the activity of uveitis and might be useful in monitoring disease progression. Complete withdrawal of medication was difficult to achieve in some cases.
ACKNOWLEDGMENTS
The authors thank Dr. Richard J Stawell (Royal Victorian Eye & Ear Hospital, Australia) and Dr. Wei Gao (University of Melbourne, Australia) for editing the manuscript.
This study was supported by a grant from the National Natural Science Foundation of China (No. 81670841).
DECLARATION OF INTEREST
The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.
FUNDING
This study was supported by a grant from the National Natural Science Foundation of China (No. 81670841).