ABSTRACT
Introduction: We evaluated visual acuity (VA) over 5 years in a subspecialty noninfectious uveitis population.
Methods: Retrospective data from 5,530 noninfectious uveitis patients with anterior, intermediate, posterior or panuveitis were abstracted by expert reviewers. Mean VA was calculated using inverse probability of censoring weighting to account for losses to follow-up.
Results: Patients were a median of 41 years old, 65% female, and 73% white. Initial mean VA was worse among panuveitis (20/84) than posterior (20/64), intermediate (20/47), and anterior (20/37) uveitides. On average, mean VA improved by 0.62, 0.51, 0.37, and 0.26 logMAR-equivalent lines over 2 years, respectively (each P < .001), then remained stable, except posterior uveitis mean VA worsened to initial levels.
Conclusion: Mean VA of uveitic eyes improved and, typically, improvement was sustained under uveitis subspecialty care. Because VA tends to improve under tertiary care, mean VA change appears a better outcome for clinical studies than time-to-loss of VA.
Acknowledgments
We thank the MUST Research Group for providing visual acuity data through 5 years from the MUST Trial and Follow-up Study for comparison to the SITE visual acuity data.
Declaration of Interest Statement
Maxwell Pistilli, Marshall M. Joffe, Sapna S. Gangaputra, Siddharth S. Pujari, Douglas A. Jabs, Grace A. Levy-Clarke, Hosne Begum, Tonetta D. Fitzgerald, and Nirali P. Bhatt, report no conflicts of interest. James T. Rosenbaum serves or has served as a consultant for Abbott Laboratories, Amgen, Allergan, Genentech, Novartis, and UCB and has been involved in clinical trials for Abbott Laboratories, Genentech, Lux Biosciences, and Eyegate Pharma. Jennifer E. Thorne serves as a consultant for Allergan and XOMA. C. Stephen Foster serves as a lecturer for Alcon, Inspire, Ista, and Centocor; as a Consultant for Sirion; as a consultant and lecturer for Allergan and Bausch & Lomb; and as an equity owner for EyeGate. John H. Kempen serves or has served in the last 3 years as a consultant for Clearside, Gilead, and Santen and has received grant funding from EyeGate.