ABSTRACT
Purpose: To measure and compare posterior ocular layers in remission period in children with familial Mediterranean fever (FMF).
Methods: A randomly selected eye and fellow eye of 20 FMF patients and 20 control eyes were evaluated. The average age of patients and control subjects were 12.9 ± 2.7 and 13.4 ± 2.7, respectively (p = .57). Peripapillary retinal nerve fiber layer thickness, optic nerve head parameters, macular ganglion cell inner plexiform layer and ganglion cell complex thickness, foveal and parafoveal vascular densities, superficial/deep foveal avascular zone area and choroidal thickness were measured using swept source optical coherence tomography angiography.
Results: Among the overall measurements, temporal quadrant parafoveal vessel density of patients was significantly higher than that of controls (49.20 ± 2.57% vs 47.14 ± 3.17%, p = .04) and nasal quadrant vessel density was lower (42.88 ± 4.13% vs 46.76 ± 3.18%, p = .02).
Conclusions: This study indicated that FMF as an autoimmune disease may affect foveal vascular structure in children besides multiple other organ involvement.
Declaration of Interest
The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.