Fluorescein Angiography Scoring System Using Ultra-Wide–Field Fluorescein Angiography Versus Standard Fluorescein Angiography in Patients with Sarcoid Uveitis

ABSTRACT

Purpose: To compare standard fluorescein angiography (FA) and ultra-wide-field (UWF) FA in evaluating sarcoid uveitis activity using the scoring system adopted by the Angiography Scoring for Uveitis Working Group (ASUWG).

Methods: Standard and UWF FA images of 36 eyes with sarcoid uveitis were acquired on the same day. Three graders independently graded 72 FA images using the ASUWG scoring system. We evaluated inter-observer variability using the intra-class correlation coefficient (ICC) and compared scores of each angiographic sign.

Results: The ICC was 0.77 for standard FA and 0.87 for UWF FA, with respective total scores of 12.0 and 14.6. UWF FA had higher scores than standard FA for optic disc hyperfluorescence, posterior retinal vascular staining and/or leakage, and peripheral capillary leakage.

Conclusions: The scores for UWF FA had a higher ICC than those for standard FA in evaluating sarcoid uveitis. Peripheral capillary leakage scores were particularly high for UWF FA.

KEYWORDS:

• Ocular sarcoidosis
• sarcoid uveitis
• fluorescein angiography scoring system
• ultra-wide–field fluorescein angiography
• ultra-wide–field scanning laser ophthalmoscopy

Acknowledgments

We thank Fukumi Fujikake for taking the fluorescein angiography photographs.

The manuscript was edited for English grammar by a native writer at Enago.

Declaration of interests

The authors report no conflicts of interests. The authors alone are responsible for the content and writing of the paper.

Additional information

Funding

This work was supported by JSPS KAKENHI [grant numbers 16K11281 and 19K09986].