ABSTRACT
Purpose: To validate the revised criteria of the International Workshop on Ocular Sarcoidosis (IWOS) for the diagnosis of ocular sarcoidosis (OS).
Methods: A retrospective chart review study was performed on 323 patients including 51 patients with biopsy-proven sarcoidosis and 272 patients with other uveitis entities. Data on intraocular signs and systemic investigations were collected, and sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and the Youden index were calculated.
Results: All intraocular signs and most systemic investigations showed high diagnostic parameters. Sensitivity, specificity, PPV, and NPV of the revised IWOS criteria were 1.000, 0.930, 0.728, and 1.000, respectively. Presumed or probable OS showed lower sensitivity and higher specificity when compared with the best Youden index.
Conclusion: The revised IWOS criteria are useful in Japanese patients, but could possibly be improved by modifying the criterion of presumed or probable OS.
Acknowledgments
The authors thank Professor Jun Miyauchi, Director of Pathology Division, Department of Central Laboratory, Saitama City Hospital, Saitama, Japan, for critically editing this manuscript.
Disclosure of interest
The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.