Neuro-Behcet Disease and Ocular Inflammation: A Case Report and Literature Review

ABSTRACT

Purpose: To describe a case of panuveitis with occlusive vasculitis leading to the diagnosis of neuro-Behcet disease (NBD) and discuss the relationship between uveitis and NBD.

Methods: Case report with a literature review of ocular inflammation in NBD.

Results: A 26-year-old woman with a seven-month history of recurrent cerebral venous sinus thromboses (CVST) and right-sided hemiparalysis secondary to rhombencephalitis presented with bilateral panuveitis and occlusive retinal vasculitis. Systemic evaluations were negative for hypercoagulability and infection. Although HLA-51 negative, the diagnosis was consistent with NBD.

Conclusion: NBD is a rare subset of BD with a limited number of studies and patients. However, uveitis is more common in adults with parenchymal disease; may predate the development of neurological symptoms. The most common locations of ocular inflammation were posterior and panuveitis. MRI/V of the brain can identify enhancing lesions in the rhombencephalon or CVST in patients with uveitis with neurological findings.

KEYWORDS:

• Neurobehcet disease
• uveitis
• cerebral venous sinus thrombosis
• rhombencephalitis
• occlusive retinal vasculitis

Declaration of Interest

All authors do not have a conflict of interest to disclose.