Creating a Health Utility Value for Birdshot Chorioretinopathy

ABSTRACT

Purpose

To create a health utility value for birdshot chorioretinopathy (BCR) using Time Trade-Off (TTO) and Standard Gamble (SG) utilities.

Method

Adult BCR patients completed TTO, SG, EQ-5D-5L, and NEI VFQ-25 questionnaires and underwent a detailed history and clinical examination.

Results

A total of 28 BCR patients (9 M, 19 F; mean age 62 years, range 47–83) were included. There were 22 patients with a logMAR vision of 0.3 or better in both eyes. Mean TTO was 0.90 ± SD 0.18 (range 0.33–1.0) and mean SG was 0.94 ± SD 0.14 (range 0.5–1.0). TTO correlated with EQ-5D-5L index value (p = .024) and NEI VFQ-25 composite score (p = .015).

Conclusions

Of 28 patients with BCR, 11 would trade remaining life (mean 5.4 years), and 6 would take a risk of immediate death (mean 28% risk), in return for perfect vision in both eyes for the rest of their life.

KEYWORDS:

• Birdshot chorioretinopathy
• quality of life
• time trade-off
• standard gamble
• EQ-5D-5L
• NEI VFQ-25

Acknowledgments

Preliminary results from this work were presented at the fourth Birdshot Uveitis Day, November 2018, London. It was also accepted as poster presentations at the Association for Research in Vision and Ophthalmology 2020 Annual Meeting, and the Royal College of Ophthalmologists Annual Congress 2020 but could not be presented because of the COVID-19 pandemic.

Declaration of Interest

The authors report no conflicts of interest.

Additional information

Funding

This work was supported by a grant from Fight for Sight/Birdshot Uveitis Society [#24BU172].