Correlation between Subfoveal Choroidal Thickness and Anterior Segment Inflammation in Patients with Chronic Stage of Vogt-Koyanagi-Harada Disease

ABSTRACT

Purpose

To correlate changes in subfoveal choroidal thickness (SCT) with the degree of anterior inflammatory activity in chronic Vogt-Koyanagi-Harada (VKH) disease.

Methods

Anterior segment inflammation was assessed using SUN anterior chamber cell grading criteria, and SCT was measured using EDI-OCT in patients with VKH at multiple visits. ANOVA was used to compare the mean SCT for each anterior chamber cell grade. Regression analysis was used to correlate the anterior segment cell grade and the SCT.

Results

14 patients were included in the study. A total of 432 data points consisting of SCT and anterior segment cell values were analyzed. ANOVA demonstrated significant difference between the mean SCT for different anterior chamber cell grades (p < .0001). Regression analysis demonstrated significant correlation between SCT and grade of anterior chamber cells (R² = 0.37, p < .001).

Conclusions

Chronic VKH is characterized by a dynamic change in SCT that correlates with anterior segment inflammatory activity.

KEYWORDS:

• Vogt Koyanagi Harada Disease
• uveitis
• subfoveal choroidal thickness
• anterior segment inflammation
• EDI-OCT

Abbreviations

ART	=	Automated Real-time Tracking
EDI	=	Enhanced Depth Imaging
RPE	=	Retinal Pigment Epithelium
SD-OCT	=	Spectral Domain Optical Coherence Tomography
SUN	=	Standardization of Uveitis Nomenclature
VKH	=	Vogt Koyanagi Harada Disease

Declaration of Interest

QDN is a recipient of a Physician Scientist Award from Research to Prevent Blindness, New York, NY, and serves on the Scientific Advisory Board for AbbVie, Bayer, Genentech, Regeneron, and Santen, among others.

Finding

No funding was received for this project.