ABSTRACT
Introduction
We evaluated the associations of clinical and demographic characteristics with visual acuity (VA) with over 5 years in a subspecialty noninfectious uveitis population.
Methods
Retrospective data from 5,530 noninfectious uveitis patients were abstracted by expert reviewers, and contemporaneous associations of VA with demographic and clinical factors were modeled.
Results
Patients were a median of 41 years old, 65% female, and 73% white. Eyes diagnosed ≥5 years prior to cohort entry had worse VA (−1.2 lines) than those diagnosed <6 months prior, and eyes with cataract surgery performed prior to entry had worse VA (−5.9 lines) than those performed during follow-up. Vitreous haze (−4.2 lines for 3+ vs quiet), hypotony (−2.5 lines for ≤5 mm Hg vs 6–23 mm Hg), and CNV (−1.8 lines) all were strongly associated with reduced VA.
Conclusion
Factors associated with reduced VA included well-known structural complications, and lack of subspecialty care during cataract surgery.
KEYWORDS:
Declaration Of Interest Statement
Maxwell Pistilli, Sapna S. Gangaputra, Siddharth S. Pujari, Douglas A. Jabs, Grace A. Levy-Clarke, Hosne Begum, Tonetta D. Fitzgerald, and Nirali P. Bhatt, report no conflicts of interest. James T. Rosenbaum serves or has served as a consultant for Abbott Laboratories, Amgen, Allergan, Genentech, Novartis, and UCB and has been involved in clinical trials for Abbott Laboratories, Genentech, Lux Biosciences, and Eyegate Pharma. Jennifer E. Thorne serves a consultant for Allergan and XOMA. C. Stephen Foster serves as a lecturer for Alcon, Inspire, Ista, and Centocor; as a Consultant for Sirion; as a consultant and lecturer for Allergan and Bausch & Lomb; and as an equity owner for EyeGate. John H. Kempen serves as a consultant (DSMC Chair) for Gilead.