Varicella Zoster Viral Retinitis following Chimeric Antigenic Response T-cell Therapy for B-cell Lymphoma

ABSTRACT

Purpose

To describe the first case of varicella zoster virus (VZV) retinitis following chimeric antigenic response (CAR) T-cell therapy.

Methods

Case review.

Results

A 53-year-old male was treated with CAR T-cell therapy for refractory diffuse large B-cell lymphoma. Nine months after CAR T-cell therapy, he developed VZV skin infection and retinitis. The retinitis responded to systemic acyclovir therapy and intravitreal ganciclovir.

Conclusion

VZV retinitis can occur following CAR T-cell immunotherapy.

KEYWORDS:

• Chimeric antigenic response T-cell therapy
• retinitis
• varicella zoster virus
• B-cell
• lymphoma

Declaration of interest

The authors declare no conflict of interest. The authors alone are responsible for the content and writing of the paper

Additional information

Funding

This work was supported by King Saud University through Vice Deanship of Research Chair, Dr. Nasser Al-Rashid Research Chair in Ophthalmology (Abu El-Asrar AM), Riyadh, Saudi Arabia.