Two Cases of Extremely High-IL-6 Pan-uveitis with Subretinal Exudation and Cell Migration

ABSTRACT

Purpose

To describe two cases of extremely high-IL-6 pan-uveitis with subretinal exudation and cell migration.

Methods

Pre-operative and postoperative images and IL-6 values in vitreous samples of two pan-uveitis cases were analyzed.

Results

Case 1 was a 76-year-old man with blurry vision in his right eye. Fundus examination and optical coherence tomography showed vitreous opacification with vitreous cells and the presence of a white-yellowish retinal exudate with peripheral choroidal detachment all around. The IL-6 value was 16,600 pg/ml. Case 2 was a 63-year-old man with blurry vision in his right eye. On fundus examination, there was severe vitreous opacification in his right eye. The IL-6 value was 26,600 pg/ml. Importantly, there was good responsiveness to steroids and the TNF inhibitor.

Conclusion

Unclassified intraocular inflammation might include a new category of disease with unilateral pan-uveitis with good response to steroid therapy and extremely high vitreous IL-6 values.

KEYWORDS:

• IL-6
• uveitis
• vitrectomy
• case series

Declaration of interest

The authors declare that they have no competing interests.

Contributions

MT wrote the main text of the manuscript and prepared the figures. Datasets were prepared by MT and NM. SH reviewed the manuscript and checked the statistical analysis. All authors have read and approved the manuscript in its final form.

Ethics approval and consent to participate

All procedures performed in studies involving human participants were conducted in accordance with the ethical standards of the Institutional and/or National Research Committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards. Approval for this study was obtained prior to the start of the study from the institutional review board at Osaka City University, Japan (IRB-4239). Written, informed consent for the storage of patient information in the hospital database and use in research was provided by all patients enrolled in the study.

Additional information

Funding

None of the authors have any financial.