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Ocular Immunology and Inflammation Volume 30, 2022 - Issue 7-8
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Original Articles

Optical Coherence Tomography Angiography Findings of Iris Ischemia and Reperfusion in Cytomegalovirus Panuveitis

Federico Zicarellia Eye Clinic, Department of Biomedical and Clinical Science “Luigi Sacco”, Sacco Hospital, University of Milan, Milan, ItalyCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-7967-3440
, MDORCID Icon,
Salvatore Parrullia Eye Clinic, Department of Biomedical and Clinical Science “Luigi Sacco”, Sacco Hospital, University of Milan, Milan, ItalyORCID Iconhttps://orcid.org/0000-0001-5455-1965
, MDORCID Icon,
Alessandro Torreb Department of Infectious Diseases, ASST Fatebenefratelli-Sacco, Milan, Italy
, MD,
Marta Oldania Eye Clinic, Department of Biomedical and Clinical Science “Luigi Sacco”, Sacco Hospital, University of Milan, Milan, Italy
, MD &
Alessandro Invernizzia Eye Clinic, Department of Biomedical and Clinical Science “Luigi Sacco”, Sacco Hospital, University of Milan, Milan, Italy;c Save Sight Institute, Discipline of Ophthalmology, Sydney Medical School, The University of Sydney, Sydney, New South Wales, AustraliaORCID Iconhttps://orcid.org/0000-0003-3400-1987
, MDORCID Icon
Pages 1595-1598 | Received 07 Dec 2020, Accepted 06 Apr 2021, Published online: 11 Jun 2021
 
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ABSTRACT

Purpose

To report a case of iris ischemia in an eye affected by Cytomegalovirus (CMV)-related Chronic Retinal Necrosis (CRN) with partial reperfusion after antiviral therapy demonstrated by optical coherence tomography angiography (OCTA).

Methods

Retrospective case report. Multimodal imaging was performed at each follow-up visits.

Results

At baseline, the clinical findings and PCR on aqueous confirmed the diagnosis of CMV-induced CRN, while OCTA and Fluorescein Angiography showed multi-sectoral retinal and iris non-perfusion. After three weekly intravitreal injections of Foscarnet and retinal photocoagulation, the clinical and angiographic picture improved, with partial reperfusion of both retinal and iris vasculature.

Conclusion

Retinal and iris non-perfusion in CRN can be partially reversible, if prompt treatment is administered. OCTA of the anterior segment allowed an accurate follow-up of the iris vasculature and its perfusion.

Declaration of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

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