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ABSTRACT
Background
Neuromyelitis Optica Spectrum Disorder (NMOSD) is a rare disease marked by CNS demyelination with a predilection for the optic nerve and spinal cord often resulting in severe vision loss. We aimed to characterize uveitis occurring in the setting of NMOSD.
Methods
Retrospective chart review
Results
Of 572 NMOSD patients, 1% were found to have uveitis with a relative risk of 6.2 (95% confidence interval 3–14, p < .001) compared to the general population. The mean age of uveitis onset was 50 years, and that of NMOSD onset was 52 years. Bilateral anterior uveitis was the most common subtype and most patients were treated with rituximab for their NMOSD. A uveitis attack preceded onset of demyelination attacks in 67% of patients. Eyes without optic neuritis had a mean visual acuity at last follow-up of 20/22.
Conclusion
Uveitis is a rare complication of NMOSD, bilateral anterior uveitis was the most common subtype.
Declaration of interest
The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the article.
Financial disclosures
ARC—expert witness fees, consulting for US Nutraceuticals, and Horizon Therapeutics (not conflicting with this manuscript); JFA—consulting for Allergan Inc, Bayer Healthcare Pharmaceuticals, DORC International, bv/Dutch Ophthalmic, received royalties from Springer SBM LLC, and received research grant support from Topcon Medical Systems Inc. (not conflicting with this manuscript).