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Ocular Immunology and Inflammation Volume 30, 2022 - Issue 7-8
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Original Articles

Correlation of Clinical Aqueous Flare Grading to Semi-Automated Flare Measurements Using Laser Flare Photometry

Muhammad Sohail Halima Byers Eye Institute, Stanford University, Palo Alto, California, USA;b Ophthalmology, Ocular Imaging Research and Reading Center, Sunnyvale, California, USAView further author information
, MD,
Murat Hasanreisoglua Byers Eye Institute, Stanford University, Palo Alto, California, USA;c Department of Ophthalmology, Gazi University, School of Medicine, Ankara, Turkey;d Department of Ophthalmology, Koc University Medical School, Istanbul, Turkey;e KUTTAM, Koç University Research Center for Translational Medicine, Koç University, Istanbul, TurkeyView further author information
, MD,
Neil Onghansenga Byers Eye Institute, Stanford University, Palo Alto, California, USAView further author information
, MD,
Anh N.T. Trana Byers Eye Institute, Stanford University, Palo Alto, California, USAView further author information
, BS,
Muhammad Hassana Byers Eye Institute, Stanford University, Palo Alto, California, USAView further author information
, MD,
Mervenur Yilmazc Department of Ophthalmology, Gazi University, School of Medicine, Ankara, TurkeyView further author information
, MD,
Asadu Segawac Department of Ophthalmology, Gazi University, School of Medicine, Ankara, TurkeyView further author information
, MD,
Gokhan Gurelikc Department of Ophthalmology, Gazi University, School of Medicine, Ankara, TurkeyView further author information
, MD,
Rubbia Afridia Byers Eye Institute, Stanford University, Palo Alto, California, USAView further author information
, MD,
Maria Soledad Ormaecheaa Byers Eye Institute, Stanford University, Palo Alto, California, USA;f Department of Ophthalmology, Hospital Universitario Austral, Pilar, Buenos Aires, ArgentinaView further author information
, MD,
Gunay Uludaga Byers Eye Institute, Stanford University, Palo Alto, California, USAView further author information
, MD,
Cem Kesimd Department of Ophthalmology, Koc University Medical School, Istanbul, TurkeyView further author information
, MD,
Nam V. Nguyenb Ophthalmology, Ocular Imaging Research and Reading Center, Sunnyvale, California, USAView further author information
, BS,
Jeong Hun Baea Byers Eye Institute, Stanford University, Palo Alto, California, USAView further author information
, MD, PhD,
Jung Huynh Parka Byers Eye Institute, Stanford University, Palo Alto, California, USAView further author information
, MD, PhD,
Diana V. Doa Byers Eye Institute, Stanford University, Palo Alto, California, USAView further author information
, MD,
Mohamed A. Ibrahimb Ophthalmology, Ocular Imaging Research and Reading Center, Sunnyvale, California, USAView further author information
, MD,
Yasir J. Sepaha Byers Eye Institute, Stanford University, Palo Alto, California, USAView further author information
, MD &
Quan Dong Nguyena Byers Eye Institute, Stanford University, Palo Alto, California, USACorrespondence[email protected]
View further author information
, MD, MSc show all
Pages 1906-1912 | Received 09 Feb 2021, Accepted 18 Aug 2021, Published online: 26 Jan 2022
 
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ABSTRACT

Purpose

To compare laser flare photometry (LFP) measurements of aqueous flare with Standardization of Uveitis Nomenclature (SUN) and modified SUN grading.

Methods

In this prospective study with multicenter design, uveitis patients were classified according to SUN and modified SUN grading scales. LFP was performed with Kowa FM-700 flaremeter. Mean LFP values were compared with SUN and MSUN scores.

Results

The study included 475 LFP measurements, of which 216, 48, 150, 31, 28 and 2 had 0, 0.5+, 1+, 1.5+, 2+ and 3+ flare, respectively. LFP values were significantly different between each two consecutive steps for both clinical gradings (all P < .05). Cut-off values for modified SUN grading steps were defined as 5.7, 9.7, 15.7 and 43.2 for 0/0.5+, 0.5+/ 1+, 1+/1.5+ and 1.5/2+ borders of clinical flare, respectively.

Conclusions

LFP proves to be an objective measurement in analyzing aqueous flare comparable to both SUN and MSUN clinical grading systems.

Declaration of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

Meeting presentation

The study was presented in part at the 2019 Meeting of the American Academy of Ophthalmology, San Francisco, California, USA.

SUPPLEMENTARY MATERIAL

Supplemental data for this article can be accessed on the publisher’s website.

Additional information

Funding

Research to Prevent Blindness Departmental Challenge Award (Stanford); National Eye Institute of the National Institutes of Health (P30 EY026877) provide funding for research to Byers Eye Institute at Stanford.

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