Multiple Evanescent White Dot Syndrome Following Medigen Vaccine Biologics Corporation COVID-19 Vaccination

ABSTRACT

Purpose

To report a case of multiple evanescent white dot syndrome (MEWDS) following severe acute respiratory syndrome coronavirus 2 vaccination.

Study Design

Case report.

Results

A 36-year-old healthy Taiwanese female was presented with flashing lights in the right eye two days after the first dose of Medigen Vaccine Biologics Corporation (MVC) coronavirus disease 19 (COVID-19) vaccine. Examination of the retina revealed multiple white dots in the posterior pole extending to the mid-periphery. Disruption of ellipsoid zone on optical coherence tomography, early hyperfluorescence on fluorescein angiography, late hypo-cyanescence on indocyanine green angiography, and paracentral scotoma on visual field test were consistent with MEWDS. At four-week follow-up, the patient’s fundus lesions resolved, and symptoms subsided without treatment.

Conclusion

Resembling previous post-vaccine MEWDs cases, the symptoms are self-limited, and the visual prognosis is excellent. The presented case demonstrates MEWDS following MVC COVID-19 vaccine and suggests the immune-mediated basis for MEWDS in predisposed patients.

KEYWORDS:

• Adverse drug reaction
• multiple evanescent white dot syndrome
• MVC COVID-19 vaccine
• SARS-CoV-2
• Shoenfeld’s syndrome

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

There are no financial or non-financial competing interests.