Characterization of Fluorescein Angiography Features in Pediatric Patients with Uveitis

ABSTRACT

Purpose

To characterize fluorescein angiography (FA) features in pediatric uveitis.

Methods

A retrospective cross-sectional study of pediatric uveitis patients in Atlanta, GA, who had FA imaging between May 2009 and August 2020.

Results

A total of 137 eyes of 88 patients were evaluated. The mean FA score in anterior uveitis was lower than that in other categories (p = .0093). The mean FA score in the clinically active group was higher than that in the clinically inactive group (p = .0057). The mean FA score in eyes 20/40 or better was lower than that in other categories (p = .0292). Worse visual acuity was associated with retinal vascular staining/leakage, retinal staining/pooling, and neovascularization elsewhere. Non-infectious uveitis more often demonstrated optic disc hyperfluorescence, retinal vascular staining/leakage, capillary leakage, and pinpoint leaks, while infectious uveitis more often demonstrated retinal staining/pooling.

Conclusion

A standardized quantitative FA scoring system can be useful in the characterization of uveitis in pediatric patients.

KEYWORDS:

• Fluorescein angiography
• ocular inflammation
• pediatric imaging
• uveitis
• vascular leakage

Abbreviations and acronyms

Table

Acknowledgments

We gratefully acknowledge Dr. Jessica G. Shantha for initial conversations.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

The author(s) reported there is no funding associated with the work featured in this article.