Corneal Biomechanics in Non-infectious Uveitis Measured by Corvis ST: A Pilot Study

ABSTRACT

Purpose

To assess differences between corneal biomechanical properties in patients with non-infectious uveitis and healthy subjects using CorVis.

Methods

77 patients with non-infectious uveitis and 47 control subjects were recruited. Biomechanical parameters were measured: deformation amplitude (DA), A-1 length and A-2 length (L1, L2), A-1 velocity and A-2 velocity (V1, V2), peak distance (PD) and HC radius (highest concavity radius). AUC ROC and correlation between clinical variables and biomechanical properties were determined.

Results

Lower HC Radius and IOPb and higher DA and V1 was found in uveitis group. Statistical differences between cases using systemic medications and those with topical treatment were found in L1. Differences were showed between those cases with active and inactive uveitis in PD, DA, V2 and L2. The biomechanical parameter with the best discriminatory capacity of uveitis disease was HC Radius.

Conclusion

Differences in corneal biomechanical properties between non-infectious uveitis and healthy eyes were found.

KEYWORDS:

• Corneal stiffness
• Corvis-ST
• inflammatory activity
• intraocular pressure
• non-infectious uveitis
• ocular biomechanics

Acknowledgments

All authors declare no competing interest in the products, drugs, instruments and pieces of equipment mentioned in this manuscript.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

The author(s) reported there is no funding associated with the work featured in this article.