Multiple Sclerosis in a Patient with Intermediate Uveitis and Juvenile Idiopathic Arthritis Treated with Adalimumab: A Case Report

ABSTRACT

Purpose

To report a case of multiple sclerosis (MS) development in a patient with Juvenile Idiopathic Arthritis (JIA) and bilateral intermediate uveitis (IU) treated with Adalimumab.

Case report

A 21-year-old Colombian woman diagnosed with JIA and bilateral refractory IU treated with methotrexate and Adalimumab with difficult control of the disease and multiple ocular complications. Eight years after starting Adalimumab, the patient presented paresthesia in the left upper limb. Radiologic findings in the brain and cervical spine MRI confirmed the diagnosis of MS.

Conclusions

We reported the first case of MS development in a patient with JIA treated with Adalimumab and the third in a patient with noninfectious uveitis treated with anti-TNFα. It remains uncertain whether MS is secondary to anti-TNFα therapy or is linked to a polyautoimmunity phenomenon.

KEYWORDS:

• Adverse event
• Anti-TNF alpha
• intermediate uveitis
• multiple sclerosis
• polyautoimmunity

Acknowledgments

We thank the patient for granting permission to publish this information.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Declaration of patient consent

The authors certify that they have obtained all appropriate patient written consent forms. The patient has given her consent for images and clinical information to be reported in the journal. The patient understands that her name and initials will not be published, and due effort will be made to conceal her identity.

Additional information

Funding

The author(s) reported there is no funding associated with the work featured in this article.