Wide Field Optical Coherence Tomography and Optical Coherence Tomography Angiography in Uveitis

ABSTRACT

Background

We review the current literature on the use of wide-field optical coherence tomography (OCT) and wide-field optical coherence tomography angiography (OCTA) in different uveitic phenotypes as well as various sequelae of uveitis and discuss the limitations of this evolving technology.

Main body

Current consensus guidelines on nomenclature in wide-field OCT and OCTA are described. The specific utility of wide-field OCT and OCTA in assessment of the retina and choroid using different en-face and cross-sectional slabs in various inflammatory diseases is reviewed. Furthermore, we discuss widefield OCT and OCTA in assessment of retinal ischemia and its limitations in assessing retinal vascular leakage.

Conclusion

Wide-field OCT and OCTA deliver more sensitive measures of inflammation. With continued advancement in both hardware technology and software processing, these modalities will allow for more accurate assessment of uveitis, better understanding of disease mechanisms, and precise monitoring of treatment response.

KEYWORDS:

• Choriocapillaris
• flow void
• intermediate uveitis
• OCT
• OCTA
• Optical Coherence Angiography
• Optical Coherence Tomography
• uveitis
• vessel density
• wide-field OCT
• wide-field OCTA

Disclosure statement

No potential conflict of interest was reported by the authors.

Other financial statement

Marion R Munk: Consultant: Novartis, Zeiss, Gernsight biologics, Lumithera, Lecturer fees and travel support: Bayer.

Dilraj Grewal: Consultant: Novartis, Allergan, Genentech, EyePoint, Iveric Bio

Authors’ contributions

DSG and MM were major contributors in writing the manuscript. All authors read and approved the final manuscript.

Additional information

Funding

NIH Core Grant for Vision Research EY05722 and the Unrestricted RPB Grant from Research to Prevent Blindness Inc. (both to Duke University Department of Ophthalmology).