Predictive Factors for the Prognosis of Vogt-Koyanagi-Harada Disease

ABSTRACT

Purpose

To identify the prognostic factors in Vogt–Koyanagi–Harada (VKH) disease.

Methods

This study included 23 patients (46 eyes) with acute-phase VKHdivided into two subgroups: Group 1; acute-resolved (10 patients), group 2; chronic-recurrent (13 patients).

Results

Mean age were 29.5 ± 10.2 years in group 1, 35.8 ± 12.2 years group 2 (p = .033). Best-corrected visual acuity with logMAR at admission was 0.91 ± 0.65 in group 1, 0.88 ± 0.62 in group 2 (p = .798), and improved to 0.08 ± 0.24, 0.18 ± 0.6, respectively (p = .557). Extraocular findings were detected in 30% in group 1, and 53.8% in group 2 at the time of admission (p = .108). All patients were treated with 1 g/day 3–5 days intravenous steroid, and 10 patients had immunomodulatory treatment. Initiation of immunomodulatory therapy did not affect the prognosis (p = .676).

Conclusion

Older patients and/or who developed extraocular findings at the presentation were more prone to show recurrences.

KEYWORDS:

• Optical coherence tomography
• predictive factor
• prognosis
• uveitis
• Vogt–Koyanagi–Harada disease

Disclosure statement

The authors report no conflict of interest. The authors alone are responsible for the content and writing of the paper.

Additional information

Funding

No specific grant for this research was received from any funding agency in public, commercial or not-for-profit sectors.