Value of Chest X-Ray and Chest Computed Tomography for Systemic Sarcoidosis Diagnosis in Undifferentiated Uveitis

ABSTRACT

Background

To evaluate the contribution of chest X-ray and chest CT for the diagnosis of sarcoid uveitis.

Methods

Retrospective study on consecutive patients with uveitis of unknown etiology, who underwent both chest X-ray and CT during uveitis diagnosis workup in a tertiary French university hospital.

Results

A total of 914 patients were included. Systemic sarcoidosis was identified in 23.1%. The probability of discordance between chest X-ray and CT increased with age at diagnosis (p < 0.001). In patients 30 years of age and younger, the probability of discordance was 5% or less, and 0.8% if the ACE level was normal. After 78.3 years of age, the probability of discordance was 20% or more.

Conclusion

We recommend not to perform CT in patients under 30 years of age with a normal chest X ray and ACE level, and suggest performing chest CT first in the elderly.

KEYWORDS:

• Chest imaging
• chest X-ray
• CT scan
• sarcoidosis
• uveitis

Acknowledgment

We thank Philip Robinson for his editing word.

Authors’ contributions

CB and PS collected the data. CB and PS contributed equally to the redaction of the manuscript. Data analysis was made by CB and NRS. PS takes responsibility for the integrity and accuracy of the data. CB, PS, MF and LK participated in the clinical management of the patients enrolled in the study. All authors revised the manuscript. All authors have read and approved the final manuscript.

Consent for publication

According to French law, written consent for this study was not required due to the retrospective nature of the study.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Ethics approval and consent to participate

The present study received approval from the local ethics committee (CPP Sud Est IV) on February 2019 (number 19–31) and was registered on www.clinicaltrials.gov (NCT03877575).

Data availability statement

The data that support the findings of this study are available from the corresponding author upon reasonable request.

Supplementary material

Supplemental data for this article can be accessed online at https://doi.org/10.1080/09273948.2023.2226203

Additional information

Funding

The author(s) reported there is no funding associated with the work featured in this article.