2% Ganciclovir Controlled Posner-Schlossman Syndrome Relapse and Reduced the Chance of Corticosteroid Dependence: A Large Cohort in East China

ABSTRACT

Purpose

To present the process from acute Posner-Schlossman syndrome (PSS) relapse to remission under 2% ganciclovir (GCV), corticosteroids and anti-glaucoma agents on 323 patients.

Methods

A retrospective study enrolling 323 PSS patients. Demographics and ophthalmic examination results were generated. Patients were treated with GCV, corticosteroids and anti-glaucoma agents andfollowed up every 2–6 weeks.

Results

Patients were divided into the GCV monotherapy (N = 65, 20.12%), GCV and corticosteroids (G+C, N = 106) and GCV, corticosteroid and IOP-lowering drugs (G+C+L, N = 152) group. The G+C+L group had the highest intraocular pressure (IOP, 26.33 ± 10.26 mmHg, P < 0.001) and largest cup-to-disc ratio (0.58 ± 0.19, P < 0.05). After treatment, IOP of three groups dropped to similar level. Ninety-nine (30.65%) patients were corticosteroid-dependent whose daily corticosteroid consumption decreased after using GCV (from 2.23 ± 1.02 to 0.97 ± 0.98 drops/day).

Conclusion

2% GCV solutions worked effectively on PSS relapse with corticosteroids and anti-glaucoma agents. In patients suspected of CMV infection, proper GCV could reduce the chance of corticosteroid dependence.

KEYWORDS:

• Corticosteroids
• cytomegalovirus
• ganciclovir
• ophthalmic solutions
• Posner-Schlossman syndrome

Disclosure statement

No potential conflict of interest was reported by the author(s).

Data availability statement

Data are available upon reasonable request from the corresponding author.

Additional information

Funding

This study was funded by the Western Medicine Guidance Project of Shanghai Committee of Science and Technology [19411961600], the Experimental Animal Research Project of Shanghai Science and Technology [201409006600], and the Double Excellent Project of EENT Hospital [SYB202003]. The authors were funded by the Surface Project of National Natural Science Foundation of China [81770922, 82070957]. The funders had no role in study design, data collection, analysis and interpretation, decision to publish, or preparation of the manuscript.