Comment on Tsioti et al’s “Systemic Lipopolysaccharide Exposure Exacerbates Choroidal Neovascularization in Mice”

ABSTRACT

The study “Systemic Lipopolysaccharide Exposure Exacerbates Choroidal Neovascularization in Mice” by Tsioti et al. explores the impact of systemic lipopolysaccharide (LPS) on choroidal neovascularization (CNV) progression. The findings reveal systemic LPS exposure significantly enhances fluorescein leakage, driven by increased pro-inflammatory monocyte-derived macrophages and microglia activation. The study underscores the importance of managing systemic inflammation to mitigate CNV progression, suggesting potential therapeutic strategies targeting CSF1R inhibition and Müller cell modulation. Future research should focus on elucidating the molecular pathways involved in LPS-induced CNV exacerbation and translating these findings into clinical interventions.

KEYWORDS:

• Choroidal neovascularization
• inflammation
• lipopolysaccharide
• macrophages
• microglia

Acknowledgments

I would like to thank the authors of the referenced studies for their valuable contributions to this field.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Data availability statement

The data that support the findings of this letter are available within the cited references. No new data were created or analyzed in this study.

Additional information

Funding

The author(s) reported there is no funding associated with the work featured in this article.