ABSTRACT
This study by Ioanna Tsioti and colleagues delves into the exacerbation of choroidal neovascularization (CNV) through systemic exposure to lipopolysaccharide (LPS) in a mouse model. The research highlights the molecular and cellular mechanisms by which systemic inflammation can influence ocular conditions, particularly in the context of age-related macular degeneration (AMD). Utilizing a combination of in vivo fluorescein angiography, in situ hybridization, and flow cytometry, the study provides critical insights into the dynamic interaction between systemic inflammatory stimuli and CNV progression. Key findings include increased infiltration of monocyte-derived macrophages and enhanced Vegfα mRNA expression in Glul-expressing cells following systemic LPS exposure. These results suggest potential therapeutic targets for mitigating CNV associated with systemic inflammatory responses.
Disclosure statement
No potential conflict of interest was reported by the author(s).
CRediT authorship contribution statement
Gokul Sudhakaran: Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing.