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Ophthalmic Epidemiology Volume 25, 2018 - Issue 3
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Short Communications

Pupil Dilation May Affect Retinal Vessel Caliber Measures

Jie Jin WangCentre for Vision Research, Department of Ophthalmology and Westmead Institute for Medical Research, University of Sydney, Sydney, Australia;Office of Clinical Sciences, Duke-NUS Medical School, Singapore, SingaporeCorrespondence[email protected]
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,
Yuan ShiOffice of Clinical Sciences, Duke-NUS Medical School, Singapore, Singapore;Singapore Eye Research Institute, SingaporeView further author information
,
Jing XieCentre for Eye Research Australia (CERA), Department of Surgery, University of Melbourne, Melbourne, AustraliaView further author information
,
Ava G. TanCentre for Vision Research, Department of Ophthalmology and Westmead Institute for Medical Research, University of Sydney, Sydney, AustraliaView further author information
,
Lauren AB HogdsonCentre for Eye Research Australia (CERA), Department of Surgery, University of Melbourne, Melbourne, AustraliaView further author information
,
Sharon LeeLudwig Engel Centre for Respiratory Research, Westmead Institute for Medical Research, University of Sydney, Sydney, Australia;Department of Respiratory and Sleep Medicine, Westmead Hospital, University of Sydney, Sydney, AustraliaView further author information
,
Meredith WickensLudwig Engel Centre for Respiratory Research, Westmead Institute for Medical Research, University of Sydney, Sydney, AustraliaView further author information
,
Victoria F. CosattoCentre for Vision Research, Department of Ophthalmology and Westmead Institute for Medical Research, University of Sydney, Sydney, AustraliaView further author information
,
Kristina KairaitisLudwig Engel Centre for Respiratory Research, Westmead Institute for Medical Research, University of Sydney, Sydney, Australia;Department of Respiratory and Sleep Medicine, Westmead Hospital, University of Sydney, Sydney, AustraliaView further author information
,
Richard LindleyGeriatric Medicine, Westmead Clinical School, University of Sydney, Sydney, AustraliaView further author information
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Lyndell L. LimCentre for Eye Research Australia (CERA), Department of Surgery, University of Melbourne, Melbourne, AustraliaView further author information
,
Paul MitchellCentre for Vision Research, Department of Ophthalmology and Westmead Institute for Medical Research, University of Sydney, Sydney, AustraliaView further author information
,
John R. WheatleyLudwig Engel Centre for Respiratory Research, Westmead Institute for Medical Research, University of Sydney, Sydney, Australia;Department of Respiratory and Sleep Medicine, Westmead Hospital, University of Sydney, Sydney, AustraliaView further author information
&
Terence C. AmisLudwig Engel Centre for Respiratory Research, Westmead Institute for Medical Research, University of Sydney, Sydney, Australia;Department of Respiratory and Sleep Medicine, Westmead Hospital, University of Sydney, Sydney, AustraliaView further author information
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Pages 234-237 | Received 04 Oct 2017, Accepted 20 Nov 2017, Published online: 29 Nov 2017
 
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ABSTRACT

Purpose: To assess the effect of pupil dilation on measures of retinal vessel caliber.

Design: Observational study with self-comparisons

Methods: Retinal photographs were taken for both eyes of 25 subjects before and after pupil dilation. Three photographic graders, masked to pupil dilation status, measured the same set of images using a computer-assisted, semi-automatic method. We compared means (standard deviations) of retinal arteriolar caliber equivalent (CRAE) and retinal venular caliber equivalent (CRVE) of the same eyes between pre- and post-dilation images. We assessed concordance correlation coefficients (CC), Bland Altman limits-of-agreements, and used linear mixed models to assess CRAE and CRVE measures associated with pupil dilation (influencing image quality), graders (observers) and right-left eye variation.

Results: We found high CCs for CRAE (0.82-0.94) and CRVE (0.87-0.94) between pre- and post-dilation images of the same eyes across the graders. Bland Altman plots showed that mean differences ranged from 0.55-3.42μm for CRAE and 1.56-2.29μm for CRVE. After adjusting for right-left eye random variation, a significant fixed effect of dilation was evident in mean CRAE in two of the three graders. There was no significant fixed effect of dilation in mean CRVE across all graders. In models including data of both eyes’ measures from pre- and post-dilation images by three graders, the fixed effect for dilation status contributed significantly to CRAE and CRVE variances whereas random effects for graders and dilation status contributed minimally.

Conclusions: Contrary to our hypothesis, we found a systematic effect of pupil dilation on retinal vessel caliber measures.

Funding/Support

Australian National Health & Medical Research Council (NHMRC, Project grant ID APP1024440 to J Wheatley, R Lindley, JJ Wang, T Amis and K Kairaitis).

Financial disclosures

None of authors has any relevant financial disclosures

Additional information

Funding

Australian National Health & Medical Research Council (NHMRC, Project grant ID APP1024440 to J Wheatley, R Lindley, JJ Wang, T Amis and K Kairaitis).

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