PER3 VNTR circadian gene is associated with arterial stiffness variable in healthy subjects

Abstract

It is established that arterial stiffness is one of the risk factors for cardiovascular morbidity and mortality. We tested the hypothesis that alterations in genetic structure of circadian gene PER3 could affect hemodynamic parameters. Previously, we showed that CLOCK gene variants had a pronounced effect on arterial vasculature. Augmentation index (AIx) was significantly higher in the PER3^5/5 group than in the PER3^4/4 and PER3^4/5 groups, whereas other hemodynamic parameters, such as RWTT, PWV, and ASI, were not significantly different.

Keywords:

• Arterial stiffness
• normotensives
• PER3
• circadian genes
• SNP