Circadian clock, cell cycle, and breast cancer: an updated review

Abstract

Some key elements are common to two fundamental periodic regulatory processes; the circadian cycle and the cell cycle. Underlying mechanisms of coordination between the two processes are critical for proper cellular functioning and physiology. Disruption in the mechanisms of one process may affect the role of other that may direct critical physiological changes and may cause severe diseases like cancer, etc. More or less persuasive evidences evolve from the breast cancer research. In this mini review, we highlighted the molecular coordination’s of the elements of circadian cycle and the cell cycle and their altered expressions associated with the genesis and progression of breast cancer.

Keywords:

• Breast cancer
• cell cycle
• circadian cycle

Acknowledgments

We are grateful to University Grants Commission, New Delhi, for providing fellowship to AS through DRS-SAP scheme sanctioned in the thrust area – Chronobiology to the School of Life Sciences, Pt. Ravishankar Shukla University, Raipur.