Ferroptosis as a biological Phase transition II: Chronotherapy of avascular and vascular tumor growth

ABSTRACT

The process of ferroptosis has become an alternative therapy to fight cancer. As a continuation of previous work, a non-autonomous model was developed for avascular and vascular tumor growth under periodic perturbations that simulate the application of a chronotherapeutically modulated treatment based on triggering the ferroptosis process. It was found that for critical amplitude and a perturbation frequency of twice the autonomous frequency in vascular growth, less complex and therefore less robust states are reached, and the tumor population decreases.

KEYWORDS:

• Chronotherapy
• biological phase transition
• ferroptosis cancer
• avascular and vascular tumor growth

Acknowledgments

Prof. Dr. A. Alzola and Prof. Dr. G. Cocho in memoriam. One of the authors (JMNV) thanked the CEPHClS of the UNAM Mexico, for the warm hospitality and the financial support by PREI-DGAPA-UNAM-2022. Finally, we thank the anonymous reviewers for their helpful comments and interesting suggestions.

Disclosure statement

No potential conflict of interest was reported by the author(s).