Daily and circadian rhythms in the activity of mixed function oxidases system in rats of different age

Abstract

An age‐associated alterations in daily and circadian changes of cytochrome P‐450‐linked monooxygenases system activity were studied using 1‐, 6‐ and 12‐months old male Wistar rats, in winter and in spring season. Cytochrome P‐450 and NADPH‐cytochrome P‐450 reductase showed 12h rhythm in all investigated age groups of animals. Cytochrome b₅ and NADH‐cytochrome b₅ reductase were characterized by a 12h daily rhythm in 1‐month old rats, but in older ones 24h circadian rhythm was found. There was not significant changes of the rhythm pattern in the activity of investigated MFO system ingredients in rats of different age, between spring and winter.

Abstracting keywords:

• Daily rhythm
• circadian rhythm
• age
• mixed function oxidases system
• cytochrome P‐450
• liver
• rats