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Journal of Modern Optics Volume 55, 2008 - Issue 4-5: 3rd European Meeting in Physiological Optics, 7–9 September 2006, Edited by Vasudevan Lakshminarayanan and Luis Diaz-Santana
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Original Articles

Compact adaptive optics system for multiphoton fundus imaging

Josef F. Bille Kirchhoff Institute of Physics, University Heidelberg, Heidelberg, GermanyCorrespondence[email protected]
,
Mikael Agopov Kirchhoff Institute of Physics, University Heidelberg, Heidelberg, Germany
,
Cristina Alvarez-diez Kirchhoff Institute of Physics, University Heidelberg, Heidelberg, Germany
,
Meng Han Kirchhoff Institute of Physics, University Heidelberg, Heidelberg, Germany
,
Nina Korablinova Kirchhoff Institute of Physics, University Heidelberg, Heidelberg, Germany
,
Ulrich von Pape Kirchhoff Institute of Physics, University Heidelberg, Heidelberg, Germany
,
Olivier La Schiazza Kirchhoff Institute of Physics, University Heidelberg, Heidelberg, Germany
,
Melanie Schwingel Kirchhoff Institute of Physics, University Heidelberg, Heidelberg, Germany
,
Hongwei Zhang Kirchhoff Institute of Physics, University Heidelberg, Heidelberg, Germany
&
Frank Müller Kirchhoff Institute of Physics, University Heidelberg, Heidelberg, Germany
 show all
Pages 749-758 | Received 15 Dec 2006, Accepted 31 Jul 2007, Published online: 02 Dec 2010
 
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Abstract

A compact adaptive optics system was developed and integrated into the system for multiphoton laser scanning ophthalmoscopy. Defocus, astigmatism, trefoil, and coma are compensated via a combination of telescope and rotating pairs of phase plates. The spherical aberration as well as all dynamic aberrations are corrected by an active micro-electromechanical (MEMS) mirror. Wavefront measurement is conducted by fast SHS and pyramid sensor devices. The MEMS-mirror based adaptive optics system was validated in a study on 60 eyes of 30 subjects.The adaptive-optical multiphoton ophthalmoscope is aimed at detecting the early onset of retinal diseases such as e.g. age-related macula degeneration.

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