Thin endometrium after radiation therapy as an unresolved treatment challenge: a case report

Abstract

Receptive endometrium is essential for successful implantation and ongoing pregnancy. Significant health issues and associated therapies, especially oncologic therapies, have potential to negatively impact future fertility in young women. Irradiation and chemotherapeutic alkylating agents are known to cause ovarian failure in most females; however, less well is characterized the impact of irradiation on uterine development and integrity. With an increasing number of cancer survivors, women are seeking infertility treatment after such therapies. Here, we present a young woman who developed ovarian failure after the treatment of acute myeloid leukemia with bone marrow transplant and preceding irradiation and chemotherapy and who was diagnosed with thin endometrial lining while seeking infertility therapy.

Chinese abstract

可受孕的子宫内膜是成功植入和进而受孕的基础。重要的健康问题和相关的治疗, 特别是肿瘤治疗, 对年轻女性未来的生育力有潜在的负面作用。众所周知, 放射治疗和烷化剂化疗对大多数女性可导致卵巢功能衰竭; 然而, 放射治疗对于子宫发育和其完整性造成的特异性影响目前了解较少。随着癌症生存者数量的增加, 经过肿瘤治疗后的女性正在探索不孕不育的治疗。本文中, 一位患有急性髓细胞白血病的年轻女性, 在前期放射治疗和化疗后成功骨髓移植, 但不可避免的发展为卵巢功能衰竭合并子宫内膜线样变薄, 在这里我们记录了对于她的不孕不育治疗探索。

Keywords:

• Oncologic treatment
• radiation therapy
• thin endometrium
• uterus

Declaration of interest

The authors report no declaration of interest.