Metabolic changes in overweight and obese women above 35 years using Ethinylestradiol/drosperinone combined contraceptive pills: a 3-year case-control study

Abstract

Objective: To assess metabolic changes in overweight and obese women above 35 years using ethinylestradiol/drosperinone combined contraceptive pills for 36 cycles.

Methods: A prospective case-control study over 3 years recruiting 202 overweight and obese women above the age of 35 years who were divided into two groups, study group (n = 90) who received Ethinylestradiol/drospirenone for 36 cycles, and control group (n = 112) to whom intrauterine device was inserted. Recording of the body weight, waist circumference, blood pressure, fasting blood glucose and fasting blood lipids including triglycerides, total cholesterol, low-density lipoprotein (LDL) cholesterol and high-density lipoprotein (HDL) cholesterol before starting the method and repeated at 12, 24 and 36 cycles of use.

Results: No significant change was observed in body weight, waist circumference, blood pressure and fasting blood glucose between the two groups (p > 0.05).There was a significant reduction in triglycerides, total and LDL cholesterol with elevation in HDL cholesterol in the study group after 24 and 36 cycles of use (p < 0.05).

Conclusion: Ethinylestradiol/drospirenone combined contraceptive pills do not alter blood pressure or affect the body weight, with favorable effects on blood lipids in overweight and obese women above the age of 35 years when used for 24–36 cycles.

Chinese abstract

目的: 评估35岁以上的超重和肥胖女性使用36个周期炔雌醇/屈螺酮复方避孕药的代谢变化。

方法: 这项3年以上的前瞻性病例对照研究招募202位35岁以上的超重和肥胖女性, 她们被分为两组, 研究组 (n = 90) 使用36个周期的炔雌醇/屈螺酮, 对照组 (n = 112) 使用宫内节育器。记录其使用前、使用12、24和36个周期后的体质量、腰围、血压、空腹血糖和空腹血脂, 其中空腹血脂包括甘油三酯、总胆固醇、低密度脂蛋白 (LDL) 胆固醇和高密度脂蛋白 (HDL) 胆固醇。

结果: 两组之间体重、腰围、血压和空腹血糖无显著变化 (ｐ>0.05) 。实验组中使用24和36个周期后甘油三酯、总胆固醇和低密度脂蛋白胆固醇显著降低, 高密度脂蛋白胆固醇显著升高 (ｐ<0.05) 。

结论: 炔雌醇/屈螺酮复方避孕药不改变血压或影响体重, 使用24－36个周期对35岁以上超重和肥胖女性的血脂具有有利影响。

Keywords:

• Blood lipids
• ethinylestradiol/drospirenone
• obese women

Declaration of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article.