The role of prophylactic use of low dose aspirin and calheparin in patients with unexplained recurrent abortion

Abstract

Objective: To study the effect of prophylactic use of low dose aspirin and heparin on patients with recurrent unexplained pregnancy loss.

Methods: Prospective case control study conducted on 180 pregnant women randomized into two equal groups. Group 1 received low-dose aspirin 75 mg and heparin 5000 IU subcutaneous every 12 h. Group 2 received no treatment.

Results: There was a statistically significant difference between the two study groups regarding number of patients who completed their first trimester (66 versus 39) (p values 0.018). The outcome regarding completion of first trimester was not related to age, BMI or number of previous abortions in both the study groups. Complications of the use of aspirin calheparin occurred in 60% of the patients. The most common complication was bruising at injection site occurring in 60% of the patients followed by bleeding gums (14.4%), gastrointestinal troubles (12.2%), epistaxis (10%) and transient thrombocytopenia in only 2.22% of the patients (Table 4).

Conclusion: The use of prophylactic dose of calheparin and aspirin is associated with increased chance of passing 1st trimester safely regardless the age, body mass index or number of abortion in women with unexplained recurrent spontaneous abortion.

Chinese abstract

目的: 研究预防性使用低剂量阿司匹林及肝素在不明原因复发性妊娠丢失患者中的作用。

方法: 对180例孕妇进行前瞻性病例对照研究, 将其随机分为两个组。组1接受低剂量阿司匹林每日75mg和肝素5000IU每12小时皮下注射一次的治疗。组2未接受治疗。

结果: 在顺利完成妊娠前三个月的患者数量上, 两组之间的差异有统计学意义 (66对39) (p值为0.018) 。该结果与年龄, BMI或既往流产次数无关。使用阿司匹林和肝素钙的并发症发生率为60%。最常见的并发症是在注射部位淤血, 发生在60％的患者中, 其次是牙龈出血 (14.4％) , 胃肠道疾病 (12.2％) , 鼻出血 (10％) 和一过性血小板减少症 (仅有2.22％) (见表4) 。

结论: 使用预防剂量的阿司匹林及肝素钙对于提高不明原因反复流产妇女的早孕成功率是非常有用的。该结论与患者的年龄、BMI及既往流产次数无关。

Keywords:

• Aspirin
• Calheparin
• unexplained recurrent abortion

Declaration of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article.