The relationship of urocortin-2 with insulin resistance patients having PCOS

Abstract

In this study, we aimed to compare the serum urocortin-2 (UCN2) levels in women with polycystic ovary syndrome (PCOS) and healthy women. Thirty-eight patients with PCOS and 41 healthy women were included in the study whose age and BMI matched. The fasting serum glucose, insulin, free testosterone, hs-CRP and UCN2 levels of the all participants were examined. HOMA-IR formula was used in order to calculate the insulin resistance. Circulating UCN2 levels were significantly elevated in women with PCOS compared with controls (142.93 ± 59.48 versus 98.56 ± 65.01 pg/ml, p = 0.002). FBG, serum insulin, hs-CRP and HOMA-IR levels were found to be increased in women with PCOS. There was a positive correlation between UCN2 and free-testosterone in only PCOS group (r = 0.235, p = 0.027). Multivariate logistic regression analyses revealed that the odds ratio for PCOS was 2.31 for patients in the highest quartile of UCN2 compared with those in the lowest quartile (OR = 2.31, 95% CI = 1.88–2.83, p=0.021). Multiple linear regression analysis revealed that HOMA-IR, hs-CRP and free-testosterone independently predicted UCN2 levels (p < 0.05). UCN2 levels were significantly higher in PCOS cases when compared to control group. UCN2 is thought to be effective on pathophysiology of PCOS by paracrine and autocrine pathways.

Chinese abstract

本研究的目的是比较多囊卵巢综合征(PCOS)妇女与健康妇女的血清尿皮质激素素-2水平(UCN2)。年龄和BMI匹配的38名PCOS患者与41名健康女性被纳入此项研究。所有受试者均检查了空腹血糖, 胰岛素, 游离睾酮, hs-CRP 和 UCN2水平。 使用HOMA-IR公式计算胰岛素抵抗。与对照组相比, PCOS妇女循环中UCN2水平显著提升 (142.93 ± 59.48 和 98.56 ± 65.01 pg/ml, p = 0.002)。FBG, 血清胰岛素水平, hs-CRP 及 HOMA-IR水平在PCOS妇女中升高。 仅在PCOS组中, UCN2和游离睾酮存在正相关 (r = 0.235,p = 0.027)。多元logistic回归分析表明与最低四分位数UCN2患者相比, UCN2四分位数最高的患者PCOS优势比为2.31 (OR =2.31, 95% CI =1.88–2.83, p = 0.021)。多元线性回归分析表明 HOMA-IR, hs-CRP 和游离睾酮可独立预测UCN2水平(p＜0.05)。与对照组相比, PCOS患者UCN2水平显著升高。通过旁分泌和自分泌的UCN2在PCOS的病理生理学被认为是有效的。

Keywords:

• Insulin
• PCOS
• urocortin-2

Acknowledgements

The authors thank M. Calan for his help with statistical calculations.

Declaration of interest

The authors declare that there are no conflicts of interest.