Elevated serum interferon γ-inducible protein-10 in women with polycystic ovary syndrome

Abstract

Background: Interferon γ-induced protein 10 kDa (IP10/CXCL10) is a chemokine related to endocrine disorders; however, the serum concentrations of IP10 in women with polycystic ovary syndrome (PCOS) have not yet been reported. Therefore, we investigated whether IP10 is increased in PCOS patients and its potential clinical value in PCOS patients.

Methods: For this research, the serum IP10, glucose, insulin, high sensitivity C-reactive protein (hs-CRP), follicle-stimulating hormone (FSH), luteinizing hormone (LH) and total testosterone (TT) concentrations were measured in 60 women with PCOS and healthy controls.

Results: The median IP10 concentration was 45.60 pg/mL [interquartile range (IQR):29.75, 79.69], which was significantly higher than that of the body mass index (BMI)-matched controls (median: 36.46 pg/mL; IQR:28.98, 45.80). In the multivariate linear regression analysis, hs-CRP and the homeostasis model assessment of insulin resistance index (HOMA2-IR) were independent predictors of the IP10 values, while FSH was inversely associated with the IP10.No significant association was observed between the IP10 and BMI, glucose, LH and TT.

Conclusions: The serum IP10 concentrations increase in women with PCOS, moreover, IP10 appears to be correlated with the inflammatory and IR statuses of PCOS. IP10 may be a potential biomarker to estimate the disease activity of PCOS.

Chinese abstract

背景: 干扰素γ诱导蛋白10 (IP10/CXCL10) 是与内分泌紊乱相关的趋化因子, 然而, 多囊卵巢综合征 (PCOS) 女性中血清IP10浓度尚未报道。因此, 我们研究了IP10在PCOS患者中是否增加以及其在PCOS患者中的潜在临床价值。

方法: 本研究测量了60例PCOS和健康对照组中血清IP10, 葡萄糖, 胰岛素, 高敏C反应蛋白 (hs-CRP), 卵泡刺激素 (FSH), 黄体生成素 (LH) 和总睾酮 (TT) 的浓度。

结果: 中位IP10浓度为45.60pg/mL [四分位数范围 (IQR) : 29.75,79.69], 明显高于体重指数 (BMI) 与之匹配的对照组 (中位数: 36.46pg/mL; IQR: 28.98,4.4580) 。在多元线性回归分析中, hs-CRP、稳态模型胰岛素抵抗指数 (HOMA2-IR) 是评估IP10值的独立预测因子, 而FSH与IP10的关系与此相反。IP10和BMI, 葡萄糖, LH和TT之间没有观察到显著的关联。

结论: PCOS患者血清IP10浓度升高, IP10似乎与PCOS的炎症和IR状态相关。 IP10可能是潜在的评估PCOS的疾病活动度的生物标志物。

Keywords:

• Biomarker
• inflammatory
• insulin resistance
• interferon γ-induced protein 10
• polycystic ovary syndrome

Acknowledgements

This study was supported by Liuzhou scientific research and technological development programs (Grant No. 2015J030506), Natural Science Foundation of Guangxi University of Chinese Medicine (Grant No.YB14030) and The Self-funded research project of Guangxi Zhuang Autonomous Region health and Family Planning Commission (Grant No. Z2015206).

Declaration of interest

The authors have declared that no competing interests exist.