TCF7L2, CAPN10 polymorphisms are associated with gestational diabetes mellitus (GDM) risks: a meta-analysis

Abstract

Several polymorphisms have been identified in transcription factor 7-like 2 (TCF7L2), and calpain-10 (CAPN10) genes. Controversial conclusions for the genetic relationship between these polymorphisms and gestational diabetes mellitus (GDM) risks were obtained. Our study aims at assessing whether these polymorphisms are associated with GDM susceptibility via a meta-analysis. A total of 19 eligible case-control articles were obtained after databases searching. A significantly increased GDM risk was observed for TCF7L2 rs7903146 (all OR > 1, p < 0.01), but not rs12255372. In addition, significant difference was observed in case/control comparison for 112/112 (GG/2R2R/TT) haplotype combination frequency of CAPN10 SNP-43/19/63 (OR = 3.32, p = 0.043). In summary, TCF7L2 rs7903146 and 112/112 haplotype of CAPN10 might be associated with GDM risks.

Chinese abstract

已鉴定出转录因子7样2(TCF7L2)和钙蛋白酶-10 (CAPN10)存在数种多态性。这些多态性和妊娠期糖尿病(GDM)风险存在有争议的相关性。我们的研究旨在通过荟萃分析评估这些多态性是否与GDM易感性相关。在数据库进行搜索后共获得19个合格的病例对照文章。观察到TCF7L2 rs7903146而不是rs12255372与GDM风险显著增加有关(全部 OR >1,p＜0.01)。另外, 在CAPN10 SNP-43/19/63(OR =3.32, p = 0.043)的12/112 (GG/2R2R/TT)单倍型组合频率的病例对照比较研究中观察到显著差异。总之, CAPN10的TCF7L2 rs7903146和112/112单体型可能与GDM风险相关。

Keywords:

• CAPN10
• GDM
• meta-analysis
• TCF7L2

Declaration of interest

The authors report no declarations of interest.