Outcomes of IVF cycles coupled with PGS by aCGH of embryos from donor and autologous oocytes, transferred after vitrification to women of advanced maternal age

Abstract

It is well documented that aneuploidy rate in preimplantation embryos increases with the mother’s age, and at the same time the number of oocytes diminishes. Consequently, for patients of advanced maternal age two options are available to overcome these limitations: use of oocytes from young donors, or use of own oocytes coupled with preimplantation genetic screening (PGS) for 24 chromosomes. However, it is not clear which strategy might be more effective. The aim of this retrospective study was to evaluate outcomes of IVF cycles coupled with transfer of vitrified embryos from donor or autologous oocytes, both with or without PGS. Our results demonstrate that while after PGS clinical pregnancy, twin pregnancy and spontaneous abortion rates are similar for embryos from donor and autologous oocytes, these rates are dramatically worse in all cycles without PGS. Therefore, PGS can be recommended as a screening method to all patients of advanced maternal age even when donor oocytes are used.

Chinese abstract

据文献记录, 植入前胚胎的非整倍体率随母亲年龄增加, 同时卵子数目减少。因此, 对于高龄患者, 有两个选择可克服这些局限：采用年轻捐赠者的卵子, 或采用自身卵子结合24条染色体植入前基因筛查（PGS）。但是, 哪种方法更有效并不清楚。这项回顾性研究的目的是结合或不结合PGS, 评估通过卵子捐赠或自体卵子来源的胚胎玻璃化冷冻后植入的IVF周期结局。我们的结果证实, 通过PGS临床妊娠, 对于捐卵和自体卵子来源的胚胎, 双胎妊娠和自然流产率相似, 这些率在所有无PGS周期中显著恶化。因此, PGS可被推荐作为一种针对高龄女性的即使采用卵子捐赠的筛查手段。

Keywords:

• Preimplantation genetic screening
• PGS
• aCGH
• aneuploidy
• IVF
• clinical pregnancy rate
• donor oocytes
• advanced maternal age

Declaration of interest

No potential conflict of interest was reported by the authors.