Strategies for overcoming oncological treatment-related ovarian dysfunction – literature review

Abstract

In the majority of developed countries, it is observed that the time for maternity is being postponed to over the 30th and even 40th year of life. A significant number of cancers are diagnosed during reproductive age, often before the first pregnancy. A fertility preservation is an important issue in oncological treatment, where there is a need for balancing between radicality and the preservation of function of reproductive organs. The authors discuss the problem of ovarian dysfunction after oncological treatment and present the possible strategies for saving the reproductive function of ovaries, including both invasive and pharmacological approaches.

Chinese abstract

在大多数发达国家, 据观察怀孕的时间被推迟到30岁以上、甚至40岁。大量的癌症被诊断于生育年龄, 通常在第一次怀孕之前。生殖力保护在肿瘤的治疗中是一个重要的问题, 在此过程中需要平衡治疗的彻底性和对生殖器官功能的保护。作者讨论肿瘤治疗后卵巢功能失调的问题和目前保存卵巢生殖功能可能的策略, 包括侵入性和药理方法。

Keywords:

• Ovarian dysfunction
• fertility
• ovarian preservation
• chemotherapy

Disclosure statement

The authors report no conflicts of interest.