https://orcid.org/0000-0002-9570-1509
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Abstract
Obesity is a major factor in development of insulin resistance (IR) and metabolic features in polycystic ovary syndrome (PCOS) patients. Nearly two-thirds patients with PCOS (30 of 37 confirmed cases of PCOS) in our previous community based study were lean, in contrast to Caucasians. Metabolic parameters including IR and β cell function have not been characterized well in this group of lean PCOS. To study the metabolic features including IR and β cell function in lean PCOS patients, 53 patients with BMI, <23 kg/m2 were compared with 71 obese PCOS and 45 age and body mass index matched controls. Lean patients had similar β cell function and IR as compared to controls and obese patients, though the latter group had more metabolic abnormality. Fasting c-peptide and its ratio to glucose were significantly higher in lean patients compared to controls. In subset of subjects with five point OGTT, disposition index and Matsuda index (MI) showed significant negative correlation with BMI and blood pressure. MI also negatively correlated with waist, WHR, and HOMAB. High fasting C-peptide is probably a class effect as is seen in both lean and obese PCOS.
Chinese abstract
在多囊卵巢综合征（PCOS）的患者中, 肥胖是发展为胰岛素抵抗(IR)和代谢综合征的主要因素。相对于白种人来说, 我们既往的研究发现, 几乎2/3的PCOS患者是瘦型的（37个确诊PCOS的病例有30例）。在瘦型PCOS组中, 代谢参数包括IR 和β细胞功能并没有很好的被纳入研究。为了研究瘦型PCOS患者的代谢特征, 比如IR 和β细胞功能, 将 53例BMI <23 kg/m2的PCOS组、71例肥胖PCOS组和45例年龄及BMI匹配的对照组纳入研究。瘦型患者的β细胞功能和IR与肥胖组和对照组相似, 虽然后者多合并代谢异常。和对照组相比, 瘦型患者的空腹C-肽以及空腹C-肽/葡萄糖明显偏高。研究发现OGTT, 配置指数和Matsuda 指数 (MI) 显示和BMI 、血压呈负相关。MI 和腰围、腰臀比（WHR）,以及 稳态模型评估胰岛细胞分泌指数（HOMA-B）呈负相关。无论在瘦型或肥胖型的PCOS患者中, 空腹C-肽都偏高。
Acknowledgments
Mr. Narender Yadav our phlebotomist. Miss. Pallavi Tiwari for recruitment of controls.
Disclosure statement
All the authors have no conflict of interest.