Abstract
Objective: This study aimed to explore an appropriate selection for the patients with single fair cleavage-stage embryo on day 3.
Methods: This study included 469 fresh transfers and 220 frozen-thawed transfers from January 2014 to June 2016. Furthermore, in 72 patients who have only 4–6 fair embryos (4–5 blastomeres) on day 3, the blastocysts were cultured to day 5 for transfer.
Results: In the fresh transfers, the clinical pregnancy rate of 4–5 blastomeres group was significantly lower than 6–7 and 8–10 blastomeres group (5.88 vs. 30.13%, p<.001and 5.88 vs. 26.09%, p < .001). In the frozen-thawed transfers, the clinical pregnancy rate of 4–5 blastomeres group was also significantly lower than 6–7 and 8–10 blastomeres group (10.00 vs. 28.57%, p = .040 and 10.00 vs. 33.33%, p = .005). For the blastocyst transfers derived from fair embryos with 4–5 blastomeres, the clinical pregnancy rate was significantly higher than single and double fair embryo transfers of similar quality (44.44 vs. 7.04%, p < .001 and 44.44 vs. 28.09%, p = .013).
Conclusions: For the patients with single fair embryo (6–7 blastomeres or 8–10 blastomeres), transfer at the cleavage stage is feasible. For the patients with single fair embryo (4–5 blastomeres), transfer of single fair embryo at the blastocyst stage or accumulating two fair embryos might be worthy of consideration.
Chinese abstract
目的:本研究旨在探讨第3天单裂卵裂期胚胎患者的合适选择。
方法:本研究自2014年1月至2016年6月, 共纳入469例新鲜移植和220例冻融移植。此外, 有72名患者在第三天只有4-6个中等胚胎(4-5个卵裂球), 培养胚泡至第5天进行移植。
结果:在新鲜移植中, 4-5个卵裂球组的临床妊娠率显著低于6-7个和8-10个卵裂球组(5.88 vs. 30.13%, p < 0.001和5.88 vs. 26.09%, p < 0.001)。在冻融移植中, 4-5个卵裂球组的临床妊娠率同样显著低于6-7个和8-10个卵裂球组(10.00 vs. 28.57%, p = 0.040 和 10.00 vs. 33.33%, p = 0.005)。对于具有4-5个卵裂球的中等胚胎来源的卵裂球移植, 临床妊娠率显著高于相近质量的单个和两个中等胚胎移植(44.44 vs. 7.04%, p < 0.001 和 44.44 vs. 28.09%, p = 0.013)。
结论:有一个中等胚胎的患者在卵裂期移植是可行的(6-7个卵裂球或者8-10个卵裂球)。有一个中等胚胎的患者(4-5个卵裂球), 在卵裂期移植单个中等胚胎或积累两个中等胚胎可能需要考虑。
Disclosure statement
The authors report no conflicts of interest.