Adropin levels in women with polycystic ovaries undergoing ovarian stimulation: correlation with lipoprotein lipid profiles

Abstract

This study aimed to investigate serum and follicular fluid (FF) adropin levels in polycystic ovary syndrome (PCOS) and normal women undergoing controlled ovarian stimulation and correlate them with the lipid and lipoprotein levels. We included 60 women (30 lean and 30 overweight) with diagnosed PCOS, and 60 age and weight-matched non-PCOS controls (30 lean and 30 overweight), under in vitro fertilization (IVF) treatment. Serum lipid and lipoprotein levels were assessed by the Abbott Architect c8000 autoanalyzer while adropin levels were determined by enzyme immunoassay. Serum and FF adropin levels were significantly lower in PCOS women compared with controls and FF adropin levels were lower than serum levels. Significantly higher serum levels of total cholesterol, LDL-C, triglycerides, apolipoprotein B, lipoprotein(a) and homocysteine were encountered in PCOS subjects, while HDL-C and apolipoprotein A1 were significantly lower compared with controls. According to univariate and multivariate analysis, serum and FF adropin levels were positively correlated with BMI and HDL-C levels and negatively correlated with LDL-C levels. Women with polycystic ovaries exhibit lipid lipoprotein alterations increasing the risk of cardiovascular diseases later in life. Our findings suggest a probable involvement of adropin both in human metabolism and in the pathophysiology of PCOS.

Chinese abstract

本研究的目的是探讨在接受控制性卵巢刺激的多囊卵巢综合征（PCOS）妇女和正常妇女体内血清及卵泡液（FF）中adropin水平以及与之相关的血脂及脂蛋白水平。研究组包括60名（30名瘦者以及30名超重者）被诊断为PCOS并接受体外受精（IVF）治疗的妇女, 另外60名年龄和体重匹配的非PCOS妇女作为对照组（30名瘦者以及30名超重者）。采用Abbott Architect c8000自动分析仪测定血脂及脂蛋白水平, 采用酶联免疫分析法测定adropin水平。与对照组相比, PCOS妇女血清和FF中 adropin水平明显低于对照组, 而FF 中adropin 水平明显低于血清。PCOS妇女血清总胆固醇、LDL-C、甘油三酯、载脂蛋白B、脂蛋白（a）和同型半胱氨酸水平显著高于对照组, 而HDL-C和载脂蛋白A1显著低于对照组。通过单因素和多因素分析, 血清和FF 中adropin水平与BMI和HDL-C水平呈正相关, 与LDL-C水平呈负相关。多囊卵巢妇女呈现的血脂脂蛋白变化增加了以后心血管疾病的风险。我们的研究结果表明, adropin可能既参与人体的新陈代谢又参与PCOS的病理生理过程。

Keywords:

• Adropin
• dyslipidemia
• polycystic ovary syndrome
• body mass index
• follicular fluid
• in vitro fertilization

Disclosure statement

The authors report no conflicts of interest.