25-Hydroxy vitamin D levels in premenopausal Turkish women with uterine leiomyoma

Abstract

We aimed to evaluate the relationship between serum 25-hydroxy vitamin D levels and the risk of uterine fibroids in premenopausal women in Turkish population in this prospective observational cross-sectional study. Sixty-eight women with at least one uterine leiomyoma ≥10 mm were compared with 56 healthy controls. Serum 25-(OH) vitamin D₃ levels were measured by electrochemiluminescence immunoassay. The groups were similar in terms of age, BMI, gravidity and parity numbers. The mean level of 25-(OH) D3 were 7.28 ± 4.94 ng/ml and 78% of patients (n = 97) had severe vitamin D deficiency ( < 10 ng/mL). Vitamin D levels were significantly lower in the study group (6.54 ± 4.66 ng/ml vs. 8.18 ± 5.16 ng/ml, respectively; p = .009). Vitamin D levels were not correlated with size, volume, localization and number of leiomyomas. Traditional covered clothing style, low education level and being housewife were risk factors for Vitamin D deficiency. This is the first study that investigates the vitamin D levels in women with leiomyomas in Turkish population. Influence of vitamin D on uterine leiomyoma formation to may lead to new preventive strategies in the future.

Chinese abstract

本文通过一项前瞻性横断面观察性研究旨在评估血清25-羟维生素D水平与绝经前土耳其妇女患子宫肌瘤风险之间的关系。本文纳入68名至少有一个子宫肌瘤≥10mm的妇女, 另外56名健康对照人群。电化学发光免疫测定法检测血清25-羟维生素D水平。两组年龄、BMI和孕产次数无明显差异。25-羟维生素D平均水平为7.28 ± 4.94ng/ml, 78%人伴有严重的维生素D缺乏（<10ng/mL）。与对照组相比, 实验组中维生素D水平明显降低（分别为6.54 ± 4.66ng/ml 和8.18 ± 5.16ng/ml; p = 0.009）。而维生素D水平与子宫平滑肌的大小、体积、位置和数量无相关性。传统的穿衣风格、低教育水平和家庭妇女是维生素缺乏症的主要危险因素。本文是调查土耳其人群中平滑肌瘤女性维生素D水平的第一项研究。而维生素D对子宫平滑肌瘤形成的影响可能成为未来新的预防策略。

Keywords:

• Vitamin D deficiency
• premenopausal women
• uterine leiomyoma

Disclosure statement

The authors declare no conflict of interest.