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Abstract
The aim of this study was to investigate a proposed correlation between the incidentally discovered undescended ovaries and their confirmed diagnosis as a polycystic ovary disease (PCOD) for all cases included, and to evaluate the role of estimated insulin like factor 3 (INSL3) circulating level in the pathogenesis of both abnormal findings. The study group (A) comprised 35 women whose ovaries had been incidentally found to be undescended during the routine laparoscopy for infertility causes, and all had been diagnosed as PCOD. The control category included two subgroups; subgroup (B) included 35 women group, diagnosed as PCOD but with normally allocated ovaries in the true pelvis, and subgroup (C) included 35 healthy women with regular menses and no signs of hyperandrogenism. Correlations between the level of INSL3 and other PCOD relevant biochemical tests: [e.g. BMI, waist-to-hip ratio (WHR), LH, FSH, androstendione (A), total and free testosterone (T & Ft), DHEA-S, and SHBG] had been also investigated. INSL3 levels were significantly higher in PCOD groups (A) and (B) compared to the healthy fertile control subgroup (C) (80.5 ± 29.4, 65.11 ± 15.6, and 41.11 ± 10.2 pg/mL, respectively), and was highest in group (A). Moreover, we identified a strong correlation between INSL3 and androstenedione (r = 0.42, p = 0.0012), and free (r = 0.42, p = .0123) and total testosterone (r = 0.41, p = .004) in the PCOD (A) and (B) subgroup compared to the levels in subgroup (C). LH was significantly higher in all PCOD women in groups (A&B) (12. 3 ± 3.4, and 11.2 ± 1.4 mIU/L, respectively) compared to those in group (A) (5.7 ± 2.5 mIU/L), with a fair correlation with INSL3. However, there was no statistically significant correlation between INSL3 and FSH, DHEA-S, glucose, basal insulin concentration or HOMA-IR in all PCOD women. The strong positive correlation between INSL3, and high ovarian androgens levels in all PCOD women, which appeared clearly in undescended polycystic ovaries could support the proposed syndrome hypothesis between those abnormal findings.
Chinese abstract
本研究旨在探讨偶然发现未下降卵巢与确诊多囊卵巢疾病（PCOD）的相关性, 评估胰岛素样因子3的循环水平在两种异常发现的发病机理中所起的作用。研究组（A）包括35名因不孕在常规腹腔镜下偶然发现卵巢未下降, 被诊为PCOD的患者。对照组包括两组；组（B）包括35名诊为PCOD, 但真骨盆内卵巢位置正常的患者, 组（C）包括35名月经正常, 无高雄征象的健康女性。INSL3和其他PCOD相关生化检查[例如体质量指数（BMI）、腰臀比（WHR）、LH、FSH、雄烯二酮（A）、总睾酮和游离睾酮（T & Ft）、DHEA-S和SHBG] 的相关性也被分析。PCOD组（A）和（B）的INSL3水平明显高于健康生育对照组（C）（分别为80.5 ± 29.4、65.11 ± 15.6和41.11 ± 10.2pg/ml）, A组最高。而且, 与组（C）相比, 我们发现PCOD（A）和（B）组中INSL3和雄烯二酮（R = 0.42, P = 0.0123）、游离睾酮（R = 0.42, P=.0123）、总睾酮（R = 0.41, P=.004）的强相关性。INSL3在所有PCOD组中（A&B）（分别12. 3 ± 3.4和11.2 ± 1.4 mIU/L）较组（A）（5.7 ± 2.5 mIU/L）中明显增高, 且与INSL3相关。然而在所有PCOD女性中, INSL3和FSH、DHEA-S、葡萄糖、基础胰岛素浓度或HOMA-IR之间均无明显相关性。在所有未下降多囊卵巢的PCOD女性中, INSL3与高卵巢雄激素水平的强正相关性, 支持两种异常发现之间所提出的综合征假说。
Acknowledgement
The authors are grateful to all the women who agreed to participate in this work, and also agreed to share their data in this research work. Also many thanks to all the colleagues and nurses in the university department who gave supporting hand to this study. The authors also confirm that they never had any funding during the study steps, nor any conflict of interest concerning this work.
Disclosure statement
The study had been approved form the local Minia University Ethical committee before the start of case recruitment.
A formal written consent had been taken form each women recruited for the work, for both sharing in the work, and for publishing the work as well.
The datasets used and/or analyzed during the current study available from the corresponding author on reasonable request.
The authors declare that they have no competing interests”
There was no funding offered for the corresponding or co-others to complete this work.